Migraine Treatment
and Prevention




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                                          What is it ?
What's inside ?
                     How it works.
                     How to use.
What is it ?

is a patented over the counter homeopathic medicine intended to be a comprehensive approach for the treatment and prevention of migraine headaches (MigraSpray can also be effective for treating the pain and symptoms associated with menstrual cycles as well as tension headaches and hangovers). Use it for the rapid treatment of a migraine attack or use it daily to dramatically reduce or eliminate the onset of migraine headache symptoms.

MigraSpray is made available only through healthcare professionals and by ordering here. MigraSpray is not available through chain retail stores or outlets.

The efficacy of MigraSpray in treating acute migraine attack was clearly demonstrated in a randomized placebo-controlled double blind crossover trial for migraine headache relief drawn from a general population. APPROXIMATELY 88% OF THE PATIENTS STUDIED RECEIVED RELIEF IN AN AVERAGE OF LESS THAN 7 MINUTES.

MigraSpray was shown to be highly effective in preventing migraine in a study of patients suffering from frequent migraines conducted by Dr. Fred Pescatore, Director of the Centers for Integrative and Complimentary Medicine in New York City and Dallas. The participants in the study used MigraSpray each day and APPROXIMATELY 90% HAD THEIR MIGRAINE ATTACKS ELIMINATED AS LONG AS THEY CONTINUED WITH REGULAR DAILY USAGE.

What's inside ?

All Natural Ingredients

MigraSpray contains only natural, standardized ingredients and there have been no reported side effects and no reports of interaction with any over-the-counter or prescription medications. MigraSpray is safe for treating migraine attacks and safe for regular daily use to prevent the onset of migraine headache symptoms. There have been no reports of Medication Overuse Headache (MOH).

MigraSpray contains the active ingredients feverfew (its primary ingredient), goldenseal dandelion and larch agaric. Feverfew has been used for centuries for the treatment of a variety of ailments including headaches, rheumatic aches, abdominal pain and menstrual cramps. Studies have shown that feverfew acts as a natural anti-inflammatory controlling the inflammation that results in cerebral blood vessel dilation, believed to cause or contribute to the symptoms of migraine headaches.

The herb Feverfew (Pyrethrum Parthenium), also known as Tanacetum parthenium, is native to Europe, although it is now commonly found in many parts of the world, including North and South America. Feverfew is a perennial plant and is classified as a member of the Asteracea or Compositea family, a relative of the daisy.

The active ingredients in Feverfew are sesquiterpene lactones, the primary component being parthenolide, a phyto-chemical. Studies have shown that parthenolide inhibits platelet aggregation and the release of serotonin from platelets. Feverfew has also been shown to inhibit pro-inflammatory prostaglandin synthesis. These anti-inflammatory properties may control the inflammation that results in cerebral blood vessel dilation, a cause or contributor to the symptoms of migraine headaches.

Feverfew has been used for centuries and originally became popular with English herbalists in the middle ages. As the name suggests, feverfew was used as an application for the treatment of “fevers.” However, the word “fever” at that time referred to a number of ailments, including rheumatic aches, abdominal pain and headaches.

Over the past two decades medical interest of feverfew has been rekindled in response to various in-vitro studies as well as the wide spread use of feverfew among the general public. A number of research groups have formally investigated the clinical use of the herb for the relief of symptoms of migraine headaches.

Several studies, including one in "The Lancet" and another in "The British Medical Journal" have demonstrated feverfew’s potential for preventative relief of migraine. These double-blind placebo studies showed a statistically significant number of patients reporting a reduction in the number and/or severity of migraine attacks.

Subsequent studies have substantiated the use of feverfew in controlling the symptoms of migraines.

MigraSpray is Proven Effective

A study testing the efficacy of using MigraSpray for prevention was conducted in New York City by Dr. Fred Pescatore, M.D., MPH, Director of the Centers for Integrative and Complimentary Medicine in New York City and Dallas. Of the patients studied using MigraSpray on a continual daily basis, approximately 90% had their migraine headache attacks eliminated.

The efficacy of MigraSpray for treating a migraine attack was also demonstrated in a randomized, placebo-controlled, double-blind, crossover trial for migraine headache relief drawn from a general population, reporting migraine headaches. The strength of this trial includes its draw from a general population, design, outside review, extremely high safety record, equal baseline characteristics between the two groups (placebo and product), and statistical significance in all the major end-point categories. The results of the trial demonstrated that nearly eighty-eight percent of the patients studied using MigraSpray received some degree of relief from their migraine headache symptoms within an average of less than 7 minutes. The results of this study are statistically significant, at a P value of less than 0.01 in all parameters.

How it works.
Sublingual Administration

Sublingual administration allows the rapid introduction of MigraSpray into the bloodstream via the blood vessels located in the highly vascularized mucous membrane under the tongue. This route of absorption bypasses the gastrointestinal tract and requires only small dosages of the active ingredients contained in MigraSpray, which reduces chances of side effects, while simultaneously enhancing the effectiveness of such ingredients.

Although many substances are absorbed sublingually, not all substances are permeable and accessible to the mucous membrane, which may function as a barrier preventing effective diffusion. NatureWell’s micro-spray technology ensures that the sublingual mucous membrane is an ideal site for such absorption.

The administration of sublingual drugs offers improved drug bioavailability and rapid metabolisation allowing more complete absorption and maximizing the benefit to the patient by permitting more precise dosage control. Sublingual drug administration is commonly applied in the field of cardiovascular drugs, steroids, certain barbiturates and enzymes and has been a developing field in the administration of many vitamins and minerals, which are found to be readily and thoroughly absorbed by this method.

Bypassing the gastro-intestinal tract with sublingual delivery not only allows MigraSpray to achieve rapid absorption, reduced degradation and enhanced effectiveness with no reported side effects, but it also serves to avoid unpleasant gastric symptoms in individuals that suffer from a variety of gastrointestinal difficulties such as ulcers, hyperactive gut, celiac disease or compromised digestion.

1. Lea, Leilani. “Sublingual Absorption.” Positive Health Complimentary Medicine Magazine.April 21, 2002.

2. Calabrese Ph.D., Edward J. and Linda A. Baldwin, “Developing Insights on the Nature of the Dose-Response Relationship in the Low Dose Zone: Hormesis as a Biological Hypothesis.” Biomedical Therapy Vol. XVI, No. 3 1998: 235-240.

How to Use.
Prevention vs Treatment

Preventing migraine symptoms means using a daily medication to help reduce the number, frequency and severity of migraines you get. Treating migraine symptoms means taking medicine at the first sign of a headache and waiting for relief. Most over-the-counter and prescription drugs indicated for migraine treatment do not work for prevention but MigraSpray does both!

Use MigraSpray daily for prevention if:

  • You typically suffer from two or more migraine attacks in any given month
  • Your migraine attacks affect your daily activities for two or more days at a time
  • Your migraine attacks negatively impact your daily routine, and acute treatments do NOT work
  • You take over-the-counter or prescription drugs more than twice per week for migraine relief


Otherwise for treatment, MigraSpray may be used as directed below at the earliest sign of a migraine.

Directions for use

At the earliest sign of a migraine attack, administer 5 full sprays of MigraSpray under the tongue and hold for 30 seconds before swallowing. Immediately repeat after swallowing and hold for another 30 seconds. (One dose is 10 full sprays of MigraSpray.)

If you have not experienced relief of your migraine within ten minutes of your first dose repeat the dose a second time. Repeat dosage every 5 minutes thereafter until relief is achieved (maximum five doses, or 50 full sprays).

Once each day, either first thing in the morning or before bed, administer 5 full sprays of MigraSpray under the tongue and hold for 30 seconds before swallowing. Immediately repeat after swallowing and hold for another 30 seconds. (10 full sprays is one dose. For maximum preventative benefit it is recommended that one dose be administered each day). Results vary, but within 30 – 60 days you should experience a dramatic reduction or elimination of your migraine headaches.

One bottle of MigraSpray is intended to last approximately 20 days when dosing once per day. If a bottle is not completed within 20 days, increase the amount of sprays each day.

Should you experience a migraine while using MigraSpray for prevention it is recommended that you also treat the attack with MigraSpray by following the instructions for treatment.